Si-free enolate Claisen rearrangements of enamido substrates.
نویسندگان
چکیده
α-Alkyl β-amino esters are available in high diastereoselectivity through a silicon-free Claisen enolate [3,3]-sigmatropic rearrangement of enamide esters. Optimisation studies have probed the crucial role of the initial enolisation and the nature of the enamide N-centre. The demonstration of chirality transfer and the formation of β-proline systems, is also presented.
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 10 7 شماره
صفحات -
تاریخ انتشار 2012